Sat next to Suu Kyi and with the news media present, Pence said her country's atrocities were "without excuse." The vice president also called on her to hold those responsible to account.
But since becoming de facto leader of Myanmar, Suu Kyi has been criticized for staying silent about her own military's violence against the Rohingya. The operation involving Buddhist militias has left thousands dead and 700,000 displaced in what the United Nations says is ethnic cleansing.
A recent United Nations report detailed mass killings and gang rapes with genocidal intent in the crackdown that drove hundreds of thousands of Rohingya from Myanmar's Rakhine state into Bangladesh.
Pence also implored Suu Kyi to protect the rights of a free press. Two Reuters journalists remain imprisoned nearly one year after being arrested while reporting on the Rohingya crisis.
"In America, we believe in democratic institutions and ideals, including a free and independent press,” Pence said. "The arrests and jailing of two journalists last fall was deeply troubling to millions of Americans."
The meeting between the two leaders and their country’s delegations took place on the sidelines of the ASEAN summit in Singapore. Pence repeatedly thanked Suu Kyi for initiating the meeting.
Suu Kyi was once heralded for her efforts to shepherd democratic reforms in the country, winning the Nobel Peace Prize in 1991 and enduring 15 years under house arrest.
Her party, the National League for Democracy, won elections in 2015 after she was released and she became Myanmar's de facto leader. The military still holds significant power, however.
Many international observers have been dismayed that she has remained largely silent about the treatment of the Rohingya. This week, Amnesty International withdrew the human rights award it presented to her in 2009.